Effects of Transcranial Direct Current Stimulation (tDCS) on Behaviour and Electrophysiology of Language Production

Autor/inn/en	Wirth, Miranka; Abdel Rahman, Rasha; Kuenecke, Janina; Koenig, Thomas; Horn, Helge; Sommer, Werner; Dierks, Thomas
Titel	Effects of Transcranial Direct Current Stimulation (tDCS) on Behaviour and Electrophysiology of Language Production
Quelle	In: Neuropsychologia, 49 (2011) 14, S.3989-3998 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2011.10.015
Schlagwörter	Stimulation; Semantics; Integrity; Correlation; Cognitive Processes; Brain Hemisphere Functions; Physiology; Language Processing; Pictorial Stimuli; Task Analysis + Suchen Sie Ihr Suchwort? Semantik; Integrität; Korrelation; Cognitive process; Kognitiver Prozess; Physiologie; Sprachverarbeitung; Fantasieanregung; Aufgabenanalyse
Abstract	Excitatory anodal transcranial direct current stimulation (A-tDCS) over the left dorsal prefrontal cortex (DPFC) has been shown to improve language production. The present study examined neurophysiological underpinnings of this effect. In a single-blinded within-subject design, we traced effects of A-tDCS compared to sham stimulation over the left DPFC using electrophysiological and behavioural correlates during overt picture naming. Online effects were examined during A-tDCS by employing the semantic interference (SI-)Effect--a marker that denotes the functional integrity of the language system. The behavioural SI-Effect was found to be reduced, whereas the electrophysiological SI-Effect was enhanced over left compared to right temporal scalp-electrode sites. This modulation is suggested to reflect a superior tuning of neural responses within language-related generators. After -(offline) effects of A-tDCS were detected in the delta frequency band, a marker of neural inhibition. After A-tDCS there was a reduction in delta activity during picture naming and the resting state, interpreted to indicate neural disinhibition. Together, these findings demonstrate electrophysiological modulations induced by A-tDCS of the left DPFC. They suggest that A-tDCS is capable of enhancing neural processes during and after application. The present functional and oscillatory neural markers could detect positive effects of prefrontal A-tDCS, which could be of use in the neuro-rehabilitation of frontal language functions. (Contains 1 figure and 3 tables.) (As Provided).
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Update	2021/2/06